Design,Development And Evaluation Of Topical Formulation Contaning Essential Oil As Antidermatophytic Agent

Abstract

In the present study an attempt was made to formulate gel containing plant extracts and essential oils and was evaluated for antimicrobial activity against different microorganism.

The plants were collected and extracted with suitable solvent. Different gels were formulated by using different concentration of polymers and extracts.

The novel drug delivery system research area of herbal drugs is an innovative work that target for phytoconstituents and plant extracts regarding the therapeutic and cosmetic usefulness of plant products particularly containing flavonoids and poly phenolic compounds. However, due to its poor lipid solubility and larger molecular size limiting their ability to pass across the lipid-rich biological membranes, resulting poor bioavailability. Different reports show a promising future of gel as an advanced form of herbal products that are better absorbed, utilized, and as a result produce better results than conventional herbal extracts. It was confirmed that Ocimum Americanum gel showed a better diffusion as well as stability profile, hence providing an attractive carrier for the delivery of various phytoconstituents present in it. The application of gel formulation as topical pharmaceutical agent and cosmetics with improved safety and efficacy results in proper utilization of herbal drugs and cost-effective pharmaceutical product.

The evaluation was done  using  cup  plate  method  for  zone  of  inhibition  and  two  fold  dilution  method  for  MIC  (Minimum  Inhibitory  Concentration).  Minimum Bactericidal concentration was also calculated. Sensitivity of microorganism to marketed products was also studied. MIC for antimicrobial activity of  plant  extracts  and  essential  oils  were  studied  prior  to  gel  formulation  to  compare the changes in activity after incorporation in polymer gel.

The gel showed promising antibacterial and antifungal activity against other strains used for the stuy. The gel was stable at room temperature.