Formulation And Evaluation Of Tamarind Based Aceclofenac Extended Release Matrix Tablets

Abstract

The present investigation is aimed at studying the applicability of tamarind gum in the design of extended release formulations of aceclofenac. PVP K30, a synthetic polymer was selected as binder. HPMC is taken as another polymer for comparison over the natural gum efficiency. Drug-excipient compatibility studies, pre-compression blend studies, tablet characteristics, in-vitro drug release and release kinetic studies were performed. Results indicated that all the blend and tablets characteristics are within the acceptable criteria. The drug release from the matrix tablets depended on the polymer concentration and increase in polymer concentration retarded the drug release effectively. HPMC polymer has shown better drug release control over the natural gum tamarind. However, the drug release was extended up to 24 hours with tamarind gum and the drug release followed zero order release kinetics with diffusion mechanism.