Development And Evaluation Of Anti Diabetic Activity Of Phytosomes For Better Therapeutic Effect Of Extract

Abstract

Hyperglycemia, a common metabolic abnormality associated with diabetes mellitus, is primarily brought on by insufficient insulin synthesis at the cellular level or/and errors in insulin action. Such an endocrine condition causes major health issues and is spreading rapidly around the globe. The widespread control of diabetes with oral drug administration without producing any side effects is still regarded as a difficult undertaking, and the rising cost of traditional treatment in developing nations is another issue of concern. Traditional preparations of herbal plant extracts in the form of medications have already drawn a lot of attention in an effort to treat these problems. Locals use the crude extract of Swertia chirayita and Zizyphus mauritiana, two prominent Nepalese medicinal plants, for a variety of ailments, including type 2 diabetes. The current study's objectives were hydroalcoholic extract extraction of plant material, phytochemical analysis of Swertia chirayita and Zizyphus mauritiana, and formulation, development, and assessment of phytosomes. This study confirms the glucose tolerance activity with help of phytosomes containing the extracts of Swertia chirayita and Zizyphus mauritiana. The increase in blood glucose level can be controlled with help of phytosomes containing these extracts, along with it phytosomes showed a sustained release activity that best fitted with Korsmeyer peppas model.