LRP5rs121908669, Genetic regulation of bone mass and susceptibility to osteoporosis

Abstract

Background and aims: Genetic epidemiological studies are necessary to develop diagnostic and treatment strategies for various diseases, including osteoporosis. The LRP5G171R  single nucleotide polymorphism SNP  is one of the pathologically proven SNPs related to bones , and there is no genotyping study for it in  all over the world. Methods: LRP5rs121908669 was detected using PCR-RFLP and DNA sequencing in EDTA blood samples. The  distribution of genotypes was studied in all bone states(normal, abnormal) i.e. abnormal= osteopenia/ osteoporosis  Results: The frequency of genotypes  were 32.65% vs 67.34% for GG, 65.62% vs 34.37% for GC and 75% vs 25% for CC in normal and abnormal groups, respectively. Conclusions: There was an association between LRP5G171R  normal and low bone mineral density BMD.