Synthesis And Docking Studies Of Innovative Pyrazole Hydrazides

Abstract

The heterocyclic chemistry is never ending and ever-growing subject. Pyrazole, a heterocyclic molecule, which leading  the pharmaceutical business due to their immense    therapeutic activities. Due to the potential biological activities of the pyrazole compounds, more research work is being conducted on these molecules and which further leads to the  large investment on pyrazoles followed by invention of new potential drugs.  An array of   pyrazole benzamides  (8a-8s) were  prepared by reacting  pyrazole hydrazides  with different aldehydes and among the synthesized molecules 8g and 8i was the lead molecules. Structures of 8a-8s were confirmed by ¹H NMR, LC-MS and IR spectroscopy and its biological activities were studied by molecular docking study and study shows almost all molecules have the activity for rheumatoid arthritis disease.