A Cross TALK OF TFPI Protein S Protein C Antithrombin III Genes And Their Expression And Markers OF Thrombogenesis In Breast Cancer A Review

Abstract

Cancer-associated thrombosis is a major cause of mortality in cancer patients. Several risk factors for developing thrombogenesis also coexist with cancer patients, such as chemotherapy and immobilization, contributing to the increased risk of cancer patients developing thrombosis compared with non-cancer patients. Cancer cells are capable of activating the coagulation cascade and other prothrombotic properties of host cells, and many anticancer treatments themselves are being described as additional mechanisms for promoting thrombosis. There is a scarcity of literature which explores the pathogenesis of thrombogenesis and its association with the cancer progression  in breast cancer patients  to the best of our knowledge.

Overall aim is to  discuss the cross-talk between TFPI, protein S, Protein C, anti-thrombin III genes and their expression in patients with breastcancer. We also aim to link the process of thrombogenesis and fibrinolysis activation in patients with breast cancer. As thrombogenesis and fibrinolysis in systemic circulation are interrelated with inflammation and endothelial function we also aim to measure markers of inflammation and endothelial activation. Ultimate goal is to find out whether the above-mentioned association could be an early predictor of the progression of   breast malignancy.