Factors Associated With Non-Adherence To Antiretroviral Treatment In The City Of Kisangani In The Drc
DOI:
https://doi.org/10.47750/Pnr.2022.13.S05.340Keywords:
Factors, non-adherence, antiretroviral treatment, Kisangani, DRC.Abstract
Introduction: The Human Immunodeficiency Virus and AIDS (HIV/AIDS) epidemic continues to mourn humanity. The population's resistance to compliance or adherence to antiretroviral treatment is a major obstacle to achieving the 95-95-95 targets. The objective pursued in this study is to determine the factors associated with non-compliance with antiretroviral treatment in the city of Kisangani.
Methods: We conducted a cross-sectional descriptive study with an analytical aim in the city of Kisangani from March 01 to June 30, 2021. The study population consisted of people living with HIV (PLHIV), aged at least 18 years old. and on antiretroviral treatment who freely consented to answer the questions. 423 PLHIV on antiretroviral treatment (ART) were recruited at the end of drug withdrawal appointments after obtaining a convenience sample. The assessment of compliance was based on the count of tablets remaining in the box on the day of restocking, the missed appointment and the number of days of antiretroviral stockout. The determinants of non-compliance were sought by multiple logistic regression during our data analyses.
Results: The average age of respondents was 39.2 ± 11 in the general population. The overall non-adherence to treatment frequency was 21.5%. Marital status (ORaj: 1.14; 95% CI: 0.701-1.897; p = 0.007), Occupation (ORaj: 0.72; 95% CI: 0.435-1.184; p = 0.1732), Breaking on ARV (ORaj: 0.1; IC95%: 0.01-0.6134; p = 0.001) was a protective factor against non-adherence, the absence of fixed accommodation can worsen the disease (ORaj: 60.16 IC 95% : 23.46-163.76); p=0.001) and the undisclosed serological status at family (ORaj: 407.33 IC 95% : 79.52-3656.09); p=0.0001) emerged as determinants of non-adherence.
Conclusion:- The frequency of non-adherence to antiretroviral treatment remains high in Kisangani. Taking determinants into account will be necessary to define strategies that will improve observance in order to boost the third objective 95 because good adherence to ARV treatment is an important parameter in viral suppression.
