Hepatoprotective Potential of Tinospora cordifolia and Eclipta alba Extract Compared with Market Formulation

Abstract

In present research randomized open experimental study design was used, the study was conducted over the duration of 3years using
120 Rabbits. The animals were divided in 12 groups of 10 animals each. Oxidative stress was induced with Paracetamol. The sample
size was calculated by using formula. All the drugs were administered orally as the schedule from immediately after Paracetamol
administration, for 7 days continued. The blood sample were withdrawn from the marginal ear vein at 0,2,15,30,45,60iand 90 days. The
single dose of all antioxidant under study including Liv-52 administered immediately after Paracetamol administration was found to be
less effective as compared to once daily administration for seven days. Oni comparisons of the efficacy of antioxidants used in this
study apparently Tinospora cordifolia was found to be most effective with respect to extent in decreasing MDA, ALT, AST levels and
increasing SOD levels. Tinospora cordifolia also brought MDA, SOD, ALT and AST levels to the control values on 45 days. Liv-52
produced more or less same results. Eclipta alba, Vitamin C reached the control values on 60 days.