“Synthesis of Novel Potential, Substituted Thiazolidinone, Azetidinone, Deriv-atives Containing Substituted, Triazole, Indole Moiety and Their Screening Effect as Antifungal, Biological Activity”

Abstract

3-chloro-4-(substitutedphenyl)-1-(3-(methylthio)-5-((5-nitro-1H-indole-1-yl) methyl)-4H-1,2,4-triazol-4-yl)azetidin-2-one 6(a-e), and 2-(substituted phenyl)-3-(3-(methylthio)-5-((5-nitro-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-4-yl)thiazolidin-4-one7(a-e) were prepared through systematic path way. Compounds 6 (a-e) were contain indole, triazole units while compounds 7(a-e) were possesses effective indole, triazole and thiazolidinone moiety. Both the compounds series 6(a-e) , and 7(a-e) were show valuable characteristics and efficacy as anti-fungal and antibacterial .These drugs derivatives were also show better inhibition activities as compare to standard drugs .These drugs were also represent less side effect. Synthesis of novel heterocyclic compounds and its derivative were very useful in medicinal chemistry, biological and, pharmacological aspects. So all these triazole, azetidinone and thiazolidinone derivatives were exhibited better useful properties.