The relationship among Insulin resistance and Carbohydrate antigen CA 19-9 in Iraqi subjects with type 2 Diabetes mellitus

Abstract

Background: Insulin resistance is a common occurrence in a variety of metabolic disorders, including metabolic syndrome (MetS) and Type 2Diabetes Mellitus (T2DM) which is a major medical problem worldwide and can be qualified as the last stage of chronic pancreatitis. As a result, the measurement of insulin resistance is required to determine the relationship between them.
Objectives:- This study is an attempt to investigate the relationship between insulin resistance and the Carbohydrate antigen CA19-9 level in type 2 diabetes mellitus patients.
Methods:- Type 2Diabetes Mellitus (T2DM) has been considered in this search. The average age of patients is (46.56±1.10) years and the average duration of the disease is (6.6±0.94) years divided into two groups. Group Ⅰ, consisting of forty patients who have type 2 diabetes mellitus with a high level of CA19-9. Group Ⅱ consisted of forty patients who have normal CA19-9 levels. Forty healthy individuals with a mean age of (44.7±1.45) years were classified as a control group. Fasting blood sugar is measured in the serum of patients, glycated hemoglobin is measured in the whole blood of patients, CA19-9 and total insulin levels were measured in serum by ELISA technique.
Results:- The mean ± SE serum level of CA19-9 in patients with T2DM in groups Ⅰ and Ⅱ are (49.933±2.004)U/ml; (16.378±0.6560)U/ml respectively were significantly higher than the mean±SE serum level in the control group (5.683±1.069)U/ml. While the mean±SE serum level of HOMA-IR for the same patients in groups Ⅰ and Ⅱ are (10.149±1.0206) and (4.005±0.5221) respectively were significantly higher than the mean±SE serum level in the control group (1.058±0.097).
Conclusion:- The blood levels of CA19-9 and HOMA-IR are positively correlated in patients with T2DM