Synthesis, and biological activity of some new 1,3 – bis ( 4 – nitro benzyl -2 - aryl hydro pyrimidine

Abstract

According to bright importance’s showed by pyrimidine and hydro pyrimidine derivatives a newly series of hydro pyrimidine derivatives was synthesized by three steps. The first step by synthesized bis Schiff base from reaction two equivalents of p-nitro benzaldehyde with one equivalent of 1,3-propane diamine (1,3-diaminopropane) to afford compound 1. The next step was to reduction the imine group by NaBH4 to afford compound 2. The finally step by cyclization compound 2 during reaction it with some arylaldehyde in constated acetic acid and refluxing the mixture for 24 to 72 hours to afford compounds 3a-h. The resulting compounds were characterized by FT-IR, 1H NMR, 13C NMR, moreover, their structures confirmed by elementary analysis (CHN). The antibacterial activity for newly synthesis compounds 3a-h screened using Staphylococcus aureus as Gram positive bacteria and Escherichia coli as Gram negative bacteria. Compounds 3a and 3h exhibited highest inhibition zone as well compounds 33 and 3g showed moderated antibacterial activity.