Synthesis, Structural Characterization Of Benzothiazole Schiff Base Metal (II) Complexes And Their Interaction With DNA

Abstract

A potential metal-based chemotherapeutic product based on a benzothiazole Schiff base and first-row transition metals was synthesized
and illustrated analytically and spectrally to investigate the biochemical priority of transition-metal drugs for molecular target DNA.
As a result of the magnetic susceptibility data, it was shown that Co (II), Ni (II) and Cu (II) complexes are paramagnetic and have an
octahedral geometry at ambient temperatures. Molar conductivity experiments showed that almost all of the complexes in dimethyl
formamide were non-electrolytes. This study examined the interactions between CT-DNA and metal (II) complexes. Therefore, the
copper(II) complex significantly improves DNA binding compared to the other complexes. Additionally, this finding was supported by
gel electrophoresis, thermal denaturation, and viscosity methods.