Evaluation Of The Relationship Between Tgf-Β Expression And Clinical Symptoms In Patients With Diabetic Nephropathy

Abstract

Background and Aims: Diabetic nephropathy (DN) is a common diabetic complication that results in chronic renal failure. It has been suggested that pro-inflammatory mediators have a significant role in the development and progression of this disease. As a result, the present study aimed to examine the association between transforming growth factor-β (TGF-β) expression and DN to define a prognostic biomarker that would accelerate DN diagnosis and treatments.

Methods: The study recruited 30 DN patients and collected demographic and clinical data on them. A real-time polymerase chain reaction was used to examine TGF-β expression in peripheral blood. For statistical analysis, the Shapiro-Wilk test, the student t-test, the Mann-Whitney U, and linear regression analysis were used.

Results and conclusion: TGF-β mRNA expression was found to be significantly linked to DN, renal impairment, and a consequent decrease in eGFR. TGF-β expression, on the other hand, had no relation to FBS or HbAlc. More research is needed to fully understand the link between hyperglycemia and TGF- gene expression, as well as the influence of this correlation on the pathogenesis of nephropathy.