Effect Of Triple Therapy And Probiotic-Assisted Treatment In Helicobacter Pylori Infection On Glycemic Control In Type 2 Diabetes Mellitus

Abstract

Background

Helicobacter pylori promotes gastrointestinal tract inflammation, which affects glucose and lipid absorption, altering lipid utilization and energy harvesting and leading to type 2 diabetes and impaired blood glucose levels.

Methodology

Patients with type 2 diabetes and Helicobacter pylori infection were recruited from the endocrinology clinic for this research investigation. Fasting blood samples were obtained before and after 2 weeks of eradication therapy, glycated haemoglobin (HbA1c) and Fasting Blood Glucose levels were assessed.

Results

62 (19 male 30.6%, 43 female 69.4%) patients with the mean age of 37.2 ± 5.9 years were recruited. The mean HbA1C levels before successful treatment was 8.2 ± 3.6 before therapy and 7.4 ± 3.7 and difference was significant (p-0.01)

Conclusion

Our findings suggest that Helicobacter pylori treatment can help decrease mean glycated haemoglobin levels in type 2 diabetic patients. More research will be needed to assess the effects of Helicobacter pylori eradication in other age groups, as well as in relation to obesity and other diseases, and it may be advantageous for people at risk of diabetes to be tested for the presence of Helicobacter pylori infection.