Negative regulation of glucose uptake by Costus pictus in L6 myotube cell line

Abstract

The leaf of Costus pictus D. Don is considered as an antidiabetic in folklore medicine
and is known to reduce the blood sugar, similar to insulin. The aim of this study is
to investigate the effect of ethanolic extract of C. pictus leaf on glucose uptake by L6
myotube cell line (skeletal muscle cells) involved in glucose utilization. Ethanolic
extract of C. pictus leaf was analyzed to study GLUT4 translocation and glucose uptake
activity, but it has no direct peripheral action at 300 µg/ml dose comparable with insulin
and metformin. The glucose uptake was not enhanced by the extract of C. pictus leaf.