Insignificant activity of extracts of Gmelina asiatica and Ipomoea digitata against skin pathogens

Authors

  • Chandrika Mahendra

Keywords:

Acne, body malodor, dandruff, Gmelina asiatica, Ipomoea digitata

Abstract

Objective: To study the antimicrobial activity of Gmelina asiatica aerial parts and
Ipomoea digitata tubers against organisms causing acne, dandruff, and body malodor.
Materials and Methods: The plant materials were extracted with petroleum ether,
chloroform, ethyl acetate, and methanol using Soxhlet extraction unit. The extracts
were tested for antimicrobial activity against Malassezia furfur, Propionibacterium
acnes, and Corynebacterium diphtheriae at 1 mg/mL, 20 mg/mL, and 50 mg/mL
concentrations, respectively. Results: The chloroform and ethyl acetate extracts of
I. digitata showed mild antibacterial activity against C. diphtheriae at 20 mg/mL and
50 mg/mL concentration levels (13‑14 mm), respectively and did not show any activity
against P. acnes. The petroleum ether extract exhibited a zone of inhibition against
C. diphtheriae at 50 mg/mL. The petroleum ether, chloroform, and ethyl acetate extracts
of G. asiatica showed zones of inhibition in the range 12‑13 mm, and of P. acnes and
C. diphtheria, at 50 mg/mL. None of the extracts showed activity against M. furfur.
The methanol extracts of both the plants failed to show any activity against all the
selected organisms. Conclusion: The study showed that the plant extracts exhibit
weak antimicrobial activity at the levels tested. Therefore, the extracts evaluated in
this study cannot be used as alternatives to existing antimicrobial agents for acne,
dandruff, and body malodor.

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Published

2015-01-28

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Section

Articles

How to Cite

Insignificant activity of extracts of Gmelina asiatica and Ipomoea digitata against skin pathogens. (2015). Journal of Pharmaceutical Negative Results, 6(1), 27-32. https://pnrjournal.com/index.php/home/article/view/87