Inefficiency of ethanolic extract of Glycyrrhiza glabra and Ziziphus mauritiana roots on androgenic alopecia

Abstract

Aim: To study the air growth promoting effect of roots of G. glabra and Z.
mauritiana in androgen (testosterone) induced male pattern baldness (androgenic
alopecia). Materials and Methods: Animals were divided into four groups and
they were attempted to made alopecic by treatment with testosterone for 3 weeks.
Group 1 (control), 2 (standard), 3 and 4 animals (test) were also treated topically with
vehicle, finasteride and ethanolic extract of Z. mauritiana roots and G. glabra roots
respectively. Animals were observed for signs of alopecia and after treatment period
one animal from each group was euthanized randomly and the skin sections from the
treated area was examined for changes in follicular morphology. Statistical Analysis:
Statistical analysis of data was carried out by one‑way ANOVA. Using Instat version 2.1
software. Results: The Group 1, 3 and 4 animals develop alopecia and their skin section
also shows bulbous and miniaturized hair follicles and prominent sebaceous gland while
Group 2 (standard antiandrogenic drug finasteride treated) animals does not develop
alopecia and skin samples also shows well‑formed follicles and normal sebaceous gland.
Conclusion: This experiments shows incapability of ethanolic extract of Z. mauritiana
and G. glabra combating androgenic alopecia