Lack of diuretic activity of water extract of leaves of Pongamia pinnata L. in rats

Abstract

Objective: To assess the diuretic potential of water extract (WE) of leaves of Pongamia
pinnata L. Materials and Methods: Different doses(500, 1000, 1500, and 3000 mg/kg)
of WE of the leaves of P. pinnata or vehicle or furosemide, reference drug was orally
administered to hydrated rats (n = 6/group) and their cumulative urine output was
monitored at hourly intervals for 6 h. Result: The WE of P. pinnata does not possess
significant (P > 0.05) diuretic activity. Conclusion: The WE of the leaves of P. pinnata
did not possess diuretic activity in rats as was claimed in traditional and folkloric medicine