No impact of neuropathy on pharmacokinetic of lamotrigine in rat model

Abstract

Purpose: The aim of the present research is to monitor any alteration in the serum
concentrations of lamotrigine (LMT) in peripheral neuropathic conditions compared
with normal conditions in a rat model. Materials and Methods: LMT concentrations
were established at 0.25, 0.5, 1, 2, 4, 6, 8, 10, 12 and 24 h post dose by high
performance liquid chromatography‑ultraviolet. After per oral administration of
10 mg/kg drug, pharmacokinetic parameters were determined from plasma drug
concentration. Later pharmacokinetic parameters of neuropathic pain induced
rats were calculated in order to estimate the possible effect of neuropathic pain on
pharmacokinetic parameters. Results: The regression coefficient determined for
LMT calibration curve was 0.99 ± 0.001. The working range for LMT was 0.5 to
2.5 µg/ml Limit of Detection (LOD 0.2 µg/ml). The maximum drug concentration
was found at 2 h. Conclusion: However, none of the pharmacokinetic parameter
showed statistically significant alteration where the results were quite stimulating for
the development of clinically useful oxcarbazepine dosage form to explore its activity
on neuropathic pain.