Solubility Enhancement Of Ketoprofen Drug By Preparing Lipids Based Formulation

Abstract

The objective of this study was aimed at designing Ketoprofen capsule formulations with improved solubility of a practically water insoluble drug, with the intent of achieving a formulation with significantly improved in vitro drug dissolution profile in comparison to reference product Redufen®. Several combinations of surfactant, oil and co- solvent try to designs capsule having supra solubility, by tailoring their combination with the objective to obtain this. The concept of increasing the solubility by virtue of application of a combination of the medium chain triglycerides and polysorbate 80 having high HLB value and ethyl acetate act as co- solvent and stabilizer for the emulsion thus arriving at compositions C4. In vitro dissolution studies on these capsules demonstrated that C4 was the most appropriate formulation with regards to its closeness in enhanced drug solubility when compared to Redufen®. Accelerated stability study on the C4 composition in HDPE packaging further demonstrated that no adverse changes occur in the optimized formulation when evaluated for parameters such as Disintegration time, drug content and in vitro dissolution.