A Study on Diabetic Patients Related To Functions of Fibroblast Growth Factor-23 on Bone Metabolism

Abstract

Aim/Purpose: -Type 2 Diabetes Mellitus affecting around major population around the world and with increasing ratio in near
future. There is modification in tissue cells which fails to respond to insulin properly.(FGF-23) Fibroblast Growth Factor-23 known
as a hormone composed of peptides circulating in blood synthesized by (osteoblast) bone cells. FGF-23 can exhibit physiological
functions in conjugation to bone metabolism like bone calcification and hematopoiesis.An important nutrient of osteoblast cells has
been a glucose and also many studies have shown significant alteration of bone formation in increased glucose level. Hyperglycemia
affects bone remodeling in cells of bones, insulin signalinginteraction and metabolism of bones through insulin receptors directly or
indirectly. Hence, this study is designed to estimate levels of FGF-23 in bone metabolism among healthy group, prediabetic and in
people suffering from type-2 diabetes mellitus.
Methods: -The type of present study is observational and is designed as a case control study performed in hospital. Total of 225
volunteers were taken in control group, prediabetes and 75 diabetes mellitus type 2patients. Standard deviation and was analyzed
using one-way ANOVA test and for further analysis for specific differences between 3 groups with post-hoc tukey test. Values of
P<0.05 was taken as significant.
Results: -Our results shows positive relationship for the parameters tested when found between the groups using test known as posthoc tukey (p<0.001).
Conclusion: -The present study gives clear insight about bone remodeling and bone formation when controlled by FGF-23 hormone
and can be predicted as biological possible bio-marker in the bone metabolism. Henceforth, more advanced studies are required for
detailed examination of FGF-23 physiological actions on bone metabolism and its inter-relationship with insulin resistance especially
diabetic patients.