Synthesis, Characterization and Antibacterial Evaluation of New Schiff Base Ligand and Its Complexes of Transition Metal Ion Zn (II), based on 6-Aminopenicillanic Acid
Keywords:
Schiff base, 6-amino penicillanic acid, Schiff base of n-butylaldehyde,Schiff base of crotonaldehyde, Schiff base of terephthaldehyde, Schiff base of furfuralAbstract
In the present research, 6-aminopenicillanic acid (6-APA) reaction with(n-butyl aldehyde, crotonaldehyde, terephthalaldehyde, furfuraldehyde)
in ethanol to procure compounds [6-(butylidene amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, 6-(but2-1-ylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6,6’-((1,4-phenylenebis (methaneylylidene))
bis(azaneylylidene))bis(3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, 6-((furan-2-ylmethylene)amino)-3,3-
dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid] respectively. The structure of synthesized compounds identified by
spectral data (FT-IR), ( 1
H-NMR), (13C-NMR) spectra and Mass Spectrometric. The Schiff base ligand and synthesis some transition metals
complexes [Zn] of this ligand were described via FTIR, UV-Visible Spectroscopy and the Atomic Absorption Spectroscopy, The antibacterial
activity of the ligand and complexes was tested against two different bacteria strains (Pseudomonas and Staphylococcus aureus). The ligand
and its complexes were discovered to have excellent inhibitory action against bacteria (Pseudomonas and Staphylococcus aureus). As a
consequence, the compounds developed might be viable alternatives for commonly used medications.
