DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium Interaction in Fuel Station Workers

Authors

  • Aizhar H. Hasan

Keywords:

DNA repair enzymes genes polymorphisms, APE1, XRCC1, cadmium level, fuel station workers.

Abstract

The interaction between heavy metals in the environment and DNA still under investigation, the association of cadmium
and DNA repair was conducted in a current study represented by apurinic/apyrimidinic endonuclease (APE1) Asp148Glu
(rs3136820) and X-ray repair cross-complementing group 1(XRCC1) Arg399Gln (28152) G>A, using CTTP-PCR, results
showed non-significant changes of Cd (p 0.965) in the station workers and the control group. The Cd level in station workers
according to work type showed non-significant differences (p 0.291). The APE1 genotyping in study groups showed significant
association with all genotypes in station workers (p 0.009, p 0.024), non-significant association with allele frequency (p 0.066).
The association XRCC 1 genotyping showed non-significant results (p 0.479, 0.0311), and non-significant with allele frequency
(p 0.164). The distribution of APE 1 and XRCC 1 genotyping in the station workers according to work types showed non-significant association with APE 1 (p 0. 255), and significant with allele frequency (p 0.000). The XRCC1 showed non-significant
association of GA, GG and workers (p 0.265) and significant association of G allele (p 0.001). The Cd levels, according to
APE 1and XRCC1 genotyping showed non-significant differences (p 0.193, p 0.0.76) respectively. conclusion: a significant
association of APE 1 with station workers, but didn’t association with Cd level and non-significant association of XRCC 1
genotyping with station works and Cd level.

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Published

2022-06-30

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Articles

How to Cite

DNA Repair Genes (APE1 and XRCC1) Polymorphisms – Cadmium Interaction in Fuel Station Workers. (2022). Journal of Pharmaceutical Negative Results, 13(2), 32-37. https://pnrjournal.com/index.php/home/article/view/204