Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19

Authors

  • Hams Hussain Hashim Al-Fattli

Keywords:

COVID-19, rs9923231, SNPs, VKORC1-1639G>A, Vitamin K.

Abstract

Coronavirus disease-2019 (COVID-19) is a devastating pandemic caused by coronavirus two infections characterized by
severe acute respiratory syndrome (SARS). It is also known as the SARS pandemic (SARS-CoV-2). Despite the release of a
spate of vaccinations to protect against coronavirus infection 2019 (COVID-19) in recent years, a cure for the ailment remains
elusive. Thrombosis is one of the consequences of the Coronavirus disease of 2019 (COVID-19), and it is frequently associated
with a poor prognosis in the affected population. Inflammation and coagulation are well-known to be related to one another;
nevertheless, more investigation on the number of thrombotic events associated with COVID-19 is required. Evidence suggests
that proteins linked with coagulation interact with SARS-related proteins. The frequency variants of each of correlated proteins
across different populations may be questioned about their probable involvement in the development of COVID-19. Using 50
patients and 25 control samples, we studied the connection between a single nucleotide polymorphism (SNP) (rs9923231) in
the Vit. K epoxide reductase complex 1 (VKORC1) gene and the presence of COVI-19 in order to establish a potential genetic
biomarker for COVID-19. An ARMS PCR was carried out to determine the percent of SNPs in each of the three groups.
Following the analysis of 75 samples, the data indicated no statistically significant changes between the case and control groups
(P. value 0.5).

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Published

2022-06-30

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Articles

How to Cite

Investigation of Relationship Between (rs9923231) SNP in (VKORC1) Gene with Incidence of COVID-19. (2022). Journal of Pharmaceutical Negative Results, 13(2), 23-31. https://pnrjournal.com/index.php/home/article/view/202