Synthesis, Antioxidant, Antibacterial and Docking Structure of New Dihydro-Pyrimidine Derivatives Containing Multi Phenol

Authors

  • Raied M. Shakir

Keywords:

Antioxidant, DPPH, FRAP, Gyrase, Hydro pyrimidine, Multi phenols,

Abstract

Newly series of 6,6’-((2-(Aryl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(2-methoxy phenol) (3a-i) were
synthesized from cyclization of 6,6’-((propane-1,3-diylbis (azanediyl)) bis(methylene)) bis(2-methoxyphenol) with several
aryl aldehyde in the presence of acetic acid. The newly compounds characterized from their IR, NMR and EIMs spectra.
The antioxidant capacity of these compounds screened by utilizing DPPH and FRAP assays. Compounds 3g and 3i exhibited
significant antioxidant capability in both assays. Docking study for these compounds as a potential inhibitors of gyrase enzyme
were carried out. Compound 3g exhibited significant inhibition with binding free energies (DG) higher than novobiocin.
compounds 2, 3a, 3b, 3f exhibited prominent DG.

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Published

2022-06-30

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Section

Articles

How to Cite

Synthesis, Antioxidant, Antibacterial and Docking Structure of New Dihydro-Pyrimidine Derivatives Containing Multi Phenol. (2022). Journal of Pharmaceutical Negative Results, 13(2), 57-68. https://pnrjournal.com/index.php/home/article/view/197