Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients

Authors

  • Shaimaa A. Al-Oubaidy

Keywords:

Metabolic syndrome, A16V SNP, MnSOD, Insulin, FBG

Abstract

Background: The metabolic syndrome (MS) is a group of clinical disorders that includes central and abdominal obesity, systemic
hypertension, insulin resistance (T2DM), and atherogenic dyslipidemia. It is also known as syndrome X, insulin resistance syndrome, and
Reaven syndrome. The current study was carried out to assess the effects of MnSOD A16V genetic polymorphism on MS incidence in the
Iraqi population.
Methods: This study included 50 patients with MS (27 male and 23 female) at range of age (22-59 Y) and 50 subjects as control group
with matching in age and genders. Insulin levels INS (µU/ml) were estimated by use of ELISA technique and insulin resistant index (IRI)
was estimated by specific formula while FBG, TC, TG, LDL-C, and HDL-C (mg/dl) were performed by use spectrophotometric method.
PCR-RFLP was done to investigation of the A16V MnSOD SNP.
Results: The results show that the MS and CONT groups had significantly significant differences in INS (U/ml) and IRI (p-value 0.05). The
results reveal statistical differences between MS and CONT genotypes AA and VV compared to AV genotypes.
Conclusion: In the Iraqi population, the A16V MnSOD SNP plays a crucial role in the occurrence and progression of MS.

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Published

2022-01-30

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Articles

How to Cite

Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients. (2022). Journal of Pharmaceutical Negative Results, 13(1), 95-99. https://pnrjournal.com/index.php/home/article/view/192