The Value of Lisnopril in Managing Impaired Fertility in Experimental Rats Following Alloxan Induced Hyperglycemia

Authors

  • Mohammed J Manna

Keywords:

Alloxan, Hyperglycemia, Lisnopril , Male infertility

Abstract

Background: It has been shown that the chronic metabolic derangement accompanying long standing hyperglycemia, both in experimental
animals and man, may alter fertility in males. This work investigate the role of lisnopril in improving fertility parameters .
Aim of the study: To evaluate the role of lisnopril with respect to fertility parameters in experimentally induced hyperglycemia in rats.
Materials and methods: Three groups of rats were subjected to alloxan induced hyperglycemia, placebo treatment (control group), and
alloxan and lisnopril treatment (study group). Each group included 10 animals. Sperm parameters, hormonal levels, markers of oxidative
stress and histophotometry were done .
Results: Sperm parameters in the form of sperm count, normal morphology, motility and number of dead sperms were significantly altered
following alloxan induced hyperglycemia (P < 0.001). The administration of lisnopril showed significant improvement in sperm parameters
(P <0.001) in addition to significant improvement in markers of oxidative stress, GSH, SOD, MDA and NO (P < 0.001), and in hormonal
levels, testosterone and FSH (P < 0.001).
Conclusion: Lisnopril is useful in optimizing fertility parameters in experimental rats following alloxan induced hyperglycemia through
antioxidant mechanisms and improved hormonal profile.

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Published

2021-06-25

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Section

Articles

How to Cite

The Value of Lisnopril in Managing Impaired Fertility in Experimental Rats Following Alloxan Induced Hyperglycemia. (2021). Journal of Pharmaceutical Negative Results, 12(2), 18-23. https://pnrjournal.com/index.php/home/article/view/172