White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats

Authors

  • Aseel Jasim Ali

Keywords:

Dimethybenz[a]anthracene, Oral mucosa, Tumorigenesis biomarkers, white tea

Abstract

Topical application of dimethybenz[a]anthracene (DMBA) on the oral mucosa is an experimental model of tumorigenesis that widely used
for assessing of chemopreventive substances. Camellia sinensis contains polyphenols and flavonoids that act as antioxidants and anticancer.
White tea infusion contains a lower concentration of polyphenols compared with green or red tea. This study aimed to investigate the effect of
using white tea infusion on the DMBA-induced oral tumor by assessing biomarkers related to the development of oral tumor. DMBA (0.5%
w/v dissolved in acetone) was applied topically to the oral mucosa, five times weekly for twelve weeks followed by tape water infusion or
white tea infusion (10% w/v) for another eight weeks. Serum biomarkers related to the tumorigenesis including, C-reactive protein (CRP),
tumor necrosis factor (TNF-α), epidermal growth factor receptor (EGFR), and carcinoembryonic antigen (CEA) were determined. Serum
level of CEA and the ratio of EGFR-to TNF-α were significantly increased in rats treated with white tea infusion compared with rats treated
with tape water. Thus, white tea infusion at 10%w/v for 8 weeks provokes oral tumor induced by a topical application of DMBA by the
evidence of a significantly increased the values of biomarkers related to tumorigenesis

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Published

2021-06-25

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Section

Articles

How to Cite

White Tea (Camellia Sinensis) Infusion Adversely Affects the Biomarkers of Oral Tumor Induced by Topical Application of Dimethylbenz[A]Anthracene in Rats. (2021). Journal of Pharmaceutical Negative Results, 12(2), 1-5. https://pnrjournal.com/index.php/home/article/view/170