Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm

Authors

  • Viktor N. Tsarev2 , R

Keywords:

acute myocardial infarction, DNA, endothelium-dependent vasodilation, periodontitis, periodontopathogenic bacteria, subgingival biofilm.

Abstract

Objective: The study of subgingival biofilm composition in patients with ischemic heart disease and concomitant periodontitis.
Study design: For the study, 45 patients with moderate chronic periodontitis were examined. They were divided into three groups. Group
1 included 15 patients with acute myocardial infarction, Group 2–15 included patients with exertional angina (pectoris) and Group 3–15
included patients without cardiovascular diseases. Dental and cardiological health condition was determined, a biochemical blood test was
conducted, brachial artery endothelium-dependent vasodilation was measured, and periodontopathogenic bacteria DNA in subgingival
biofilm was detected.
Results: Frequency of P. gingivalis, T. forsythia, and A. actinomycetemcomitans detection in Group 1 was significantly higher than in Group
3. In patients of Group 1 and Group 2 subgingival biofilm contained P. gingivalis two times more often (p=0.027), while P. intermedia –
four times less often (p=0.006) than in Group 3. Presence of P. gingivalis and A. actinomycetemcomitans was related to periodontal destruction level. Brachial artery endothelium-dependent vasodilation moderately correlated with patient’s cardiological condition (r=0.3284),
biochemical markers of atherosclerosis (r=0.6465), and frequency of P. intermedia detection in periodontal pockets (r=0.3828). Values of
brachial artery endothelium-dependent vasodilation in Group 1 and Group 2 were statistically significantly lower than in Group 3 (p<0.05).
Conclusions: A reliable relationship between parodontopathogenic bacteria colonization and development of acute myocardial infarction
was established. In all patients with chronic periodontitis, endothelial dysfunction was observed, but brachial artery endothelium-dependent
vasodilation was significantly lower in patients with concomitant cardiovascular diseases, which could be used for pathology prognosis.

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Published

2021-01-30

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How to Cite

Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. (2021). Journal of Pharmaceutical Negative Results, 12(1), 33-37. https://pnrjournal.com/index.php/home/article/view/168