Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm


  • Viktor N. Tsarev2 , R


acute myocardial infarction, DNA, endothelium-dependent vasodilation, periodontitis, periodontopathogenic bacteria, subgingival biofilm.


Objective: The study of subgingival biofilm composition in patients with ischemic heart disease and concomitant periodontitis.
Study design: For the study, 45 patients with moderate chronic periodontitis were examined. They were divided into three groups. Group
1 included 15 patients with acute myocardial infarction, Group 2–15 included patients with exertional angina (pectoris) and Group 3–15
included patients without cardiovascular diseases. Dental and cardiological health condition was determined, a biochemical blood test was
conducted, brachial artery endothelium-dependent vasodilation was measured, and periodontopathogenic bacteria DNA in subgingival
biofilm was detected.
Results: Frequency of P. gingivalis, T. forsythia, and A. actinomycetemcomitans detection in Group 1 was significantly higher than in Group
3. In patients of Group 1 and Group 2 subgingival biofilm contained P. gingivalis two times more often (p=0.027), while P. intermedia –
four times less often (p=0.006) than in Group 3. Presence of P. gingivalis and A. actinomycetemcomitans was related to periodontal destruction level. Brachial artery endothelium-dependent vasodilation moderately correlated with patient’s cardiological condition (r=0.3284),
biochemical markers of atherosclerosis (r=0.6465), and frequency of P. intermedia detection in periodontal pockets (r=0.3828). Values of
brachial artery endothelium-dependent vasodilation in Group 1 and Group 2 were statistically significantly lower than in Group 3 (p<0.05).
Conclusions: A reliable relationship between parodontopathogenic bacteria colonization and development of acute myocardial infarction
was established. In all patients with chronic periodontitis, endothelial dysfunction was observed, but brachial artery endothelium-dependent
vasodilation was significantly lower in patients with concomitant cardiovascular diseases, which could be used for pathology prognosis.







How to Cite

Significance of the Interrelations of Cardiovascular Diseases with Anaerobic Bacteria of Subgingival Biofilm. (2021). Journal of Pharmaceutical Negative Results, 12(1), 33-37.