Nutraceutical Immunomodulation on Acute Inflammation by Abdominal Plastic Surgery


  • Mara Cinthia Coelho Cavalcante


abdominoplasty, amino acids, fatty acids glutamine, heat shock protein.


Background: Abdominal plastic surgery is characterized as a surgical trauma which promotes systemic inflammation. Preoperative
nutrition can minimize postoperative complications and improve the surgical outcome. This article aims to review the role of nutrition on
inflammation in the patients submitted to abdominal plastic surgery.
Material and methods: In the present study, patients were offered two oral nutritional supplements (ONS) once a day for 7 days in
the preoperative period. The ONS1 (negative control) consists of a dairy drink, while the ONS2 (positive control) was a drink with
immunomodulatory nutraceuticals. Each patient ingested 200 ml of the supplements (ONS1 or ONS2) mixed with 50 grams of diet ice
cream. Twenty-five adult patients submitted to a full abdominoplasty were randomly divided into the ONS1 and ONS2 groups. The clinical
and laboratory evaluations were performed at three different stages: (T0) on the first day of start of supplementation; (T1) on the anesthetic
induction of the surgery; (T2), 24 h after the procedure. The evaluated parameters were: HSP27, HSP70, IL-1β, IL-6, CRP and TNF-α.
Results: There were no statistically significant differences between the experimental groups for all analyzed supplementation times.
Conclusion: Therefore, the oral nutritional supplementation using L-alanyl-glutamine, arginine, and oil mixtures with both high ω-9:ω-6
ratio and low ω-6:ω-3 ratio and containing ω-3 fatty acids (ALA, EPA and DHA) has no nutraceutical preconditioning effect on the shock
proteins and inflammatory mediators of surgical trauma that were studied.







How to Cite

Nutraceutical Immunomodulation on Acute Inflammation by Abdominal Plastic Surgery. (2021). Journal of Pharmaceutical Negative Results, 12(1), 38-47.