Impact of Hormonal Replacement Therapy on Macula and Retinal Nerve Fiber Layer in Postmenopausal Women

Authors

  • Salwa Tharek

Keywords:

Hormonal replacement therapy, macula, peripapillary nerve fiber layer, postmenopausal women, spectral domain‑optical coherence tomography

Abstract

Objective: The objective of this study was to investigate the effect of hormonal replacement therapy (HRT) in postmenopausal women on
peripapillary retinal nerve fiber layer (RNFL) and macular thickness and macular volume and to compare them with postmenopausal women
who are not on hormonal replacement therapy. Materials and Methods: The study population included postmenopausal women who are taking
HRT (n = 50) and postmenopausal women who are not taking HRT (n = 50). Peripapillary retinal nerve fiber layer and macular thickness and
macular volume were evaluated using spectral domain-optical coherence tomography. Results: There was no statistically significant difference
in all peripapillary RNFL thickness and macular thickness and volume parameters between the two groups, HRT and non‑HRT groups, except
for superior outer macular thickness and volume were significantly thicker in postmenopausal women who are taking hormonal replacement
therapy, P = 0.036 and P = 0.037, respectively. There was a positive correlation between duration on HRT with most of peripapillary RNFL
and macular thickness and macular volume, but the correlation was only significant at superotemporal peripapillary RNFL. Conclusion: Our
result does not provide strong evidence for a protective effect of postmenopausal HRT usage against ocular diseases. However, the increased
macular thickness in superior outer macula and positively correlated peripapillary retinal nerve fiber layer at superotemporal encouraged us
to think of promising positive effect of HRT on ocular structure

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Published

2019-01-29

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Section

Articles

How to Cite

Impact of Hormonal Replacement Therapy on Macula and Retinal Nerve Fiber Layer in Postmenopausal Women. (2019). Journal of Pharmaceutical Negative Results, 10(1), 63-68. https://pnrjournal.com/index.php/home/article/view/142