Biological Evaluation of Certain Plants of Family Salicaceae and Arecaceae

Authors

  • Naglaa Ismail Afifi

Keywords:

Antimicrobial, Archontophoenix, cytotoxic, Dictyosperma, Flacourtia, inducible nitric oxide synthase

Abstract

Objective: There is an increasing interest in the use of natural products to oppose human diseases. The leaves of Flacourtia rukam Zoll and
A. Mortizi, Archontophoenix alexandrae (Wendl. and Drude), and Dictyosperma album (Bory) H. Wendl. and Drude ex. Scheff were selected
for phytochemical and biological screening to search for new natural drugs. Total ethanolic extracts of the mentioned plants were subjected
to preliminary phytochemical screening followed by screening their cytotoxic, antimalarial, antimicrobial, and anti‑inflammatory activities.
Materials and Methods: The extracts were tested for the presence of various phytochemicals. The cytotoxic activity was determined
against five human cancer cell lines: melanoma, breast, oral, ovarian, and cervical cancers and two noncancerous cell lines. The antimalarial
activity was determined against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum depending
on the plasmodial lactate dehydrogenase activity. Antimicrobial screening was continued using the modified version of the CLSI method
whereas anti‑inflammatory activity was determined by measuring the activity of inducible nitric oxide synthase (iNOS). Results: Preliminary
phytochemical screening indicated the absence of alkaloids, anthraquinones, and saponins in all the extracts. The latter showed no toxicity
against the tested cancer cell lines and no activity against the tested microbes. The extract of D. album lacks the activity against D6 and
showed a moderate activity against W2 P. falciparum (IC50 = 41.7 μg/mL). D. album extract showed no inhibition for iNOS as contrary to F.
rukam and A. alexandrae extracts which showed a good inhibition (IC50 = 20 and 100 μg/mL, respectively). Conclusion: All tested extracts
lack cytotoxic and antimicrobial activities.

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Published

2019-01-29

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Articles

How to Cite

Biological Evaluation of Certain Plants of Family Salicaceae and Arecaceae. (2019). Journal of Pharmaceutical Negative Results, 10(1), 32-35. https://pnrjournal.com/index.php/home/article/view/136