Cocrystals Of Lopinavir: Effect On Drug Release And Hygroscopicity Characteristics

Abstract

Lopinavir is a BCS class II antiretroviral drug with mild hygroscopic characteristics necessitating approaches to improve dissolution and control the humidity. Cocrystals offer a suitable approach to improve dissolution and modify handling properties of substances in favourable manner. The Lopinavir was cocrystallized by solvent evaporation liquid assisted grinding and ultrasonic assisted cocrystalization. Highest drug release was seen in cocrystals prepared by solvent evaporation. The drug release was improved by twice and it was seen that ex vivo absorption also increased 1.56 times. Moisture uptake of cocrystals drastically reduced as compared with lopinavir.