Status Of Vitamin D, Parathyroid Hormone And Carotid Artery Intima Media Thickness And Its Correlation With Estimated Glomerular Filtration Rate In Patients With Chronic Kidney Disease

Abstract

Chronic kidney disease the most common feature is hypovitaminosis D leading to secondary hyperparathyroidism. This would have caused an increase in calcium and a decrease in phosphate levels. Arterial wall thickness can be measured by carotid intima media thickness test. Early detection of these changes may hint the need for a more aggressive approach towards heart disease and stroke. Ethical committee approval was obtained by Institutional Ethical committee. The study consists of 60 CKD patients divided into 3 groups based on eGFR and 20 normal healthy individuals, age and sex matched individuals between the age group of 30-60 years. Informed consent was taken from the patients and controls. Demographic data was collected followed by history regarding current health status, history of medication, alcoholism and Active smoking. Serum creatinine was estimated by alkaline picrate method, blood urea was estimated by Urease method, serum calcium level was estimated by OCPC method and serum phosphorous was estimated by Ammonium Molybdate method. Serum 25 OH vitamin D and serum will be analyzed by ELISA method. Serum PTH was estimated by ELISA method. Carotid artery ultrasound scans will be recorded for each participant with a 10-MHz linear-array transducer to measure intima media thickness. This study helpful to label an early alarming marker to prevent the worst progression of CKD by estimating Vitamin D, PTH and CIMT. The progression and complications of CKD, especially the cardiovascular complications can be prevented or at least postponed to some extent.