Ultra Deformable Nanotransethosomes: A Novel Tool To Intensify Transdermal Drug Delivery A Review

Abstract

Transdermal route has become a most favorable routes for the delivery of drugs from last few years. It conquered many disadvantages occurred with the oral route of drug delivery system such as major drawbacks is first pass metabolism. To overcome this limitation transdermic delivery system has been developed but the drug which can be delivered through transdermal route are facing barriers because few drugs’ particles are unable to penetrate through stratum corneum efficiently. To overcome this challenge our scientist and researchers have developed a new system known as ultra deformable vesicle system (UDV). In this system the drug molecule either synthetic or herbal is incorporated into vesicles which can easily penetrate deeper into skin for targeted drug delivery. Among Transferosomes and Ethosomes Transethosomes is a novel prospect for enhanced transdermal drug delivery through skin. The effective penetrability of nanotransethosomes is due to ethanol, edge activator and phospholipids. There are different methods are there for the preparation of nanotransethosomes like hot method, cold method, transmembrane pH gradient method, ethanol injection method and thin film hydration method. The UDV can be utilized for the delivery of numerous classes of drugs such as anti-arthritic, antibiotic, anticancer, antiviral and analgesic through transdermal route.