Studies on the Applicability of Natural Gums, Neem Gum and Tamarind Gum as Release Controlling Polymers

Abstract

Development and evaluation of matrix tablets of vildagliptin was proposed in the present investigation with a view of studying the applicability of two natural gums, neem gum and tamarind gum as release controlling polymers. HPMC K100 was used a reference polymer owing to its established release controlling property. Preliminary drug-excipient compatibility studies were done and confirmed the lack of incompatibility among the formulation ingredients. Precompression properties and tablet characteristics were evaluated and the results were analysed meeting the desired levels. HPMC based tablets shown prominent drug release, however the selected natural gums were proved to show controlled drug release up to 24 hours and is observed as polymer concentration dependant.