Comparison and Description of the Synthesis of New Compounds from Azetidin and the Study of their Biological Activity

Abstract

New organic compounds with one group, two groups and three groups were prepared from azetidine-2-one, respectively. That is through two first steps: New compounds with one group, two groups and three groups of azomethine were prepared, through the reaction of benzaldehyde derivatives with primary amine compounds with mono-, di- and triple-amino groups. The result was diagnosed by following TLC, FT.IR. The second step: The azomethine compounds prepared in the previous step were reacted with acetic acid dichloride with different molar numbers (1:1, 1:2, 1:3) and the spectroscopic and physical (TLC, FT.IR, H1. NMR., C13.NMR., and CHNX.) results were discussed to confirm the correctness of the structural formula of the resulting compounds. Finally, the effect of these prepared compounds on types of gram-positive and gram-negative bacteria (Escherichia Coli, Klebsiella pneumoniae, Staphylococcus aureus P.aeruginosa.) was studied and the results were compared with types of drugs available in pharmacies (Cefotaxime (C.C.X 10) 5 mg/ disc, Chloramphenicol (C.C.30) 30mg/ disc, Cefixime (C.F.M5) 10mg/ disc, Amoxicillin (A.M.C30) 30 mg/ disc). The results were very satisfactory against the growth of types of bacteria, and the reason was due to the increase in the number of azetidine-2-one rings, meaning the greater the number of these rings, the greater the killing of bacteria.