Inhibition of Ovarian Cancer Cells Growth Using Gold Nanoparticles and Silica Coated Gold Nanoparticles: In-Vitro Study

Authors

  • Salah H. Mannoush
  • Abid A. Thaker
  • Majid S. Jabir

DOI:

https://doi.org/10.47750/pnr.2022.13.03.109

Keywords:

GNPs; Si-GNPs; Cytotoxicity; Apoptosis; SKOV-3 cells.

Abstract

This research aims to employ gold nanoparticles (GNPs) and silicon-coated GNPs (Si-GNPs) as in vitro cytotoxic drugs against ovarian carcinoma cells. UV-spectrophotometer was used to characterize gold nanoparticles. GNPs and Si-GNPs were applied to ovarian cancer cells at various doses, and their anti-proliferative activity was measured using the Methyl-Thiazolyl Tetrazolium (MTT) test. Acridine-Orange/ Ethidium-bromide AO/EB, a dual stain, was used to examine apoptotic cells; a Crystal violet stain was used to evaluate cancer cells colony formation. The findings indicated GNPs and Si-GNPs' capacity to cause apoptosis as a possible antitumor agent in and ovarian cancer cell line. According to the present results, GNPs and Si-GNPs might be employed for a variety of biological applications in the future, perhaps replacing chemotherapy in the treatment of several types of cancer disorders.

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Published

2022-09-17

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Section

Articles

How to Cite

Inhibition of Ovarian Cancer Cells Growth Using Gold Nanoparticles and Silica Coated Gold Nanoparticles: In-Vitro Study. (2022). Journal of Pharmaceutical Negative Results, 13(3), 727-733. https://doi.org/10.47750/pnr.2022.13.03.109