Protective Effects Of Resveratrol Against Rotenone-Induced Rat Model Of Parkinson’s Disease

Abstract

This present study compares the effect of resveratrol which is a neuroprotective agent with the ropinirole which is the standard of care in the parkinson’s disease.The neuroprotective potential of resveratrol is dependent on its entry and bioavailability in the brain

Materials and Methods: In this study we try to find the combination effect of Resveratrol and Ropinirole together, no study has been done on this. The dose titration study on Resveratrol has not been done too. The rat model of Parkinson’s is a reliable model to assess and analyze the drug effects and also the safety profile.

Results and conclusion: This study helps to establish the dose related effect of resveratrol in rotenone induced rat model. Study findings revealed that the medication combination had more neuroprotective effectiveness than the gold standard and individual drug treatments when compared to the rotenone group.