Fibroblastic variant of Osteosarcoma: A Diagnostic Challenge

Abstract

Fibroblastic Osteosarcoma is a rare histopathological entity with unpredictable prognosis. Osteosarcoma(OS) of jaw bones have some distinct features such as older age at presentation, longer median survival, rare metastases but local recurrences.The pathogenesis is unknown and the treatment still remains controversial. Depending on predominant type of matrix, the osteoid, chondroid or collagen fibers produced by the tumor cells the osteosarcoma are subclassified into osteoblastic, chondroblastic, and fibroblastic types. The diagnoses is mainly done on the basis of clinical, radiological, histological and immunohistochemical features.