SYNERGISTIC ANTI-DIABETIC EFFECTS OF COMBINED ETHANOLIC PLANT EXTRACTS, Verbascum thapsus, Trigonella foenum graecum, Ficus semicordata AND Cocos nucifera (VTFC), IN STREPTOZOTOCIN INDUCED DIABETIC RATS: A POLYHERBAL COMBINATION

Authors

  • Rajesh Kumar Sharma, Sachin Kumar , Sachin Tyagi , Milind Pande

DOI:

https://doi.org/10.47750/pnr.2023.14.S01.132

Abstract

Objective: To evaluate synergistic antidiabetic effects of combination of ethanolic plant extracts, Vervascum thapsus (Leaves),
Trigonella foenum graecum( Seeds), Ficus semicordata (leaves) and cocos nucifera (Husk) in streptozotocin induced diabetic
rats Verbascum thapsus (Mullein), Trigonella foenum graecum (Fenugreek or Methi), Ficus semicordata (Drooping fig) and
cocos nucifera (Nariyal) are traditionally used in the treatment of various disease including diabetes mellitus. The anti-diabetic
activity of each individual plant species is well documented, but their combined or synergistic effect is unknown, so current
interest is to enhance therapeutic action and reduce the concentration of single herb, thereby decreasing adverse effects. Current
study is evaluated the hypoglycaemic activity of the combined mixture of ethanol extract of Leaves of Vebascum thapsus,
Seeds of Trigonella foenum graecum, leaves of Ficus semicordata and husk of coconut (VTFC) at different doses in
streptozotocin induced diabetic rats. Diabetic rats were treated with combined ethanolic extracts of VTFC at doses 810 mg
for 300 g rat (112.50 mg AEVT, 600 mg AETFG, 22.50 mg AECNH, 75 mg AEFS) calculated by design-expert software by
using Box Behnken design per day or glibenclamide 5 mg/body weight for 7 days. VTFC extracts significantly lowered
elevated fasting blood glucose level. The results were nearly equipotent with glibenclamide, so it is suggested that in addition
to its hypoglycaemic activity VTFC protects liver, kidney blood, pancreas against diabetic injury. This is the first synergistic
study of selected plant species to evaluate possible role for this mixture in treatment of diabetes.

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— Updated on 2023-02-01

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SYNERGISTIC ANTI-DIABETIC EFFECTS OF COMBINED ETHANOLIC PLANT EXTRACTS, Verbascum thapsus, Trigonella foenum graecum, Ficus semicordata AND Cocos nucifera (VTFC), IN STREPTOZOTOCIN INDUCED DIABETIC RATS: A POLYHERBAL COMBINATION. (2023). Journal of Pharmaceutical Negative Results, 942-961. https://doi.org/10.47750/pnr.2023.14.S01.132