IDENTIFICATION OF MIRROR REPEATS WITHIN THE Pdgf-Aa GENE OF DANIO RERIO

Abstract

Compared to other organs, the adult human heart lacks the capacity to regenerate after injury. In contrast, a zebrafish’s (Danio rerio) heart renews after amputation. It is one of the most relevant model organisms which is used to study regenerative biology. Various types of repetitive elements have been identified within the genome of different organisms. The repetitive elements can be direct, inverted, tandem, mirror repeats, etc. One such repeat which is not widely explored in Danio rerio is mirror repeats. The present study aims to determine the mirror repeats within the pdgf-aa gene of Danio rerio. The pdgf signalling plays a crucial role in initiating cardiomyocyte proliferation during Danio rerio (zebrafish) heart regeneration. Using a simple approach, we have identified mirror repeats within the pdgf-aa gene. We concluded that these mirror repeats are limited to the pdgf-aa gene and well distributed within the Danio rerio genome and other organism genomes.