TROP2 LEVEL IMPORTANCE AS PROGNOSTIC VALUE IN BREAST CANCER PATIENTS

Abstract

Background: Breast cancer  (BC)  is disease effected  the breast tissue , it's onset at female  more than male . The diagnosis of BC  depend on oncology guideline  included clinical , radiological and laboratory examination .    Trophoblast cell surface antigen 2 (TROP2) is glycoprotein molecular act as trans-membrane receptor encoded and synthesized  via tumor associated Ca signal transducer 2  (Tacstd2) gene  that located on  chromosome 1p32 .                                                                                        

Objective of the Study: At this study explain high TROP2 marker expression in malignant BC patients via used  Immunohistochemical method , and use it as prognostic value for BC disease .                                                                                     

Materials and Methods: This study is done at Al-Yarmook Teaching Hospital from ........  2020 to .....2022  , included 60 individuals classified into malignant and non-malignant of BC .All individuals applied under examinations then detected presence of TROP2 marker via Immunohistochemical method .                                                    

Results: Present study appeared high different value for TROP2 marker expression between malignant and non-malignant BC groups . TROP2 expression was high percent in malignant BC group compared with non-malignant group.                             

 Conclusion: The present study confirmed role of TROP2 marker expression  at BC progression and used it as prognostic value to BC disease .