PREPARATION AND EVALUATION OF NIOSOMAL HYDROGEL OF AMIKACIN AND ITS BIOLOGICAL EVALUATION

Authors

  • Neetu Singh , Dr. Deepak Marothia , Reena Singh

DOI:

https://doi.org/10.47750/pnr.2023.14.02.88

Abstract

Three different works combine to form a HF-3 dosage form, which is best on the basis of drug diffusion, in-vitro mucoadhesion and viscosity high solubility and, ease to use with adhesive nature over the skin, all three advantages are a must whenever we talk about the dermal formulation. The same happens with the drug amikacin, whose stability with minor solubility enhanced by the solid dispersion formation and encapsulated inside the vesicles called niosomes for sustained release and easy to adhere over the wound surface and finally, niosomes are encapsulated in hydrogels which provides the adhesive nature with easy to apply surety, at the same time it is able to provide a cooling sensation with surety to cure the wound. Also, drug and excipients have no interaction with each other and are quite stable in all dosage forms. Lastly all niosomal and hydrogel formulation compare with each other and proof that NF-8 as niosomal preparation and HF-3 as hydrogel preparation are overall best formulation and selected on the basis of many evaluation parameters. Finally one can conclude that whenever we select an oral route for targeting wound, there is a problem face by patient-related with improper amount of drug reached to the selected area and dose-related side effects and lastly patients non-compliance  with tablet, for all this type of problems we can use the drug to be apply over the wound directly and for this prepared formulation NF-3 is best among all other formulation in case  when we want to decrease dose frequency, directly applicable procedure and easy to use, and did not want any dose-related side effects as very less amount of drug used which is directly apply over wound and lastly slow or sustained drug release with almost whole drug penetrate from the wound which further help in heal the wound in less time duration.

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Published

2023-01-01 — Updated on 2023-01-01

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How to Cite

PREPARATION AND EVALUATION OF NIOSOMAL HYDROGEL OF AMIKACIN AND ITS BIOLOGICAL EVALUATION. (2023). Journal of Pharmaceutical Negative Results, 699-711. https://doi.org/10.47750/pnr.2023.14.02.88