Role Of Ocular Vestibular Myogenic Potential In Prediction Of Outcome In Idiopathic Intracranial Hypertension

Abstract

Background Idiopathic intracranial hypertension (IIH) is characterized by an increase in intracranial pressure (ICP). The present work aimed to assess ability of ocular vestibular evoked myogenic potentials (oVEMP) in evaluating the extent of clinical and subclinical impairment of the central nervous system in patients with Idiopathic Intracranial Hypertension (IIH), and clinical outcome after cerebrospinal fluid (CSF) tapping.

Methods A Prospective human study was carried out on forty female patients with IIH aged from 18 to 60 years between 2019 and 2021. They were subjected to clinical assessment, ocular vestibular myogenic potential before and after therapeutic CSF tapping at Neuro-Diagnostic &Research Center (NDRC), Beni-Suef University Hospital. Forty age and sex matched normal volunteers were also included as a control group.

Results Patients with (IIH) after CSF tapping showed There was significant increase of the N1-P1 amplitude of oVEMP from 3.4 (1.9) to 3.9 (2.3) μV with (P=0.012). However, after CSF tapping, when compared patients to controls, the oVEMP amplitude in patients did not reach the controls values 3.9 (2.3) to 6.6 (3.8) μV with (P=0.001).

Conclusion The amplitude of oVEMP is the most sensitive parameter to detect improvement in IIH after therapeutic CSF tapping.