A Comparative Evaluation Of Nebulized Ketamine Versus Nebulized Magnesium Sulfate On The Incidence And Intensity Of Post-Operative Sore Throat In Patients Undergoing Controlled General Anaesthesia - A Prospective Randomised Comparative Double-Blind Study

Abstract

Background and Aims: Tracheal intubation is associated with a greater incidence of sore throat ranging from 5.8% to 34%. The prophylactic management of Post-Operative Sore Throat (POST) is recommended   to   improve the quality of post‑ anaesthesia care, though the symptoms resolve spontaneously without any treatment in most of the cases. The aim of the study is to compare the effect of nebulisation of ketamine with nebulisation of magnesium sulphate on the incidence and intensity of postoperative sore throat following oral endotracheal intubation in patient undergoing general anaesthesia.

Patient and Methods: A prospective comparative double-blind randomized study was conducted on 124 patients after inclusion and exclusion criteria. Patients were divided into two groups: Group K (n=62) included patients who received nebulized ketamine (0.5 mg/ kg body weight) made upto to 5ml in normal saline and Group M (n=62) includes patients who received MgSO4 (20 mg/ kg body weight) made upto to 5ml in normal saline. Incidence and severity of post-operative sore throat were assessed at 0, 2, 4, 12 and 24 hours post extubation. Result: The overall incidence of sore throat was significantly higher in group M (50%) as compared to group K (27.42%) (p value=0.01). At 0 hour, none of the patients in both the groups complained of sore throat and the severity was significantly more in Group M as compared to Group K at 2,4 and 12hours (p value<0.05).

Conclusion: It can be concluded that ketamine nebulization significantly reduced severity and incidence of post-operative sore throat compared to magnesium sulfate nebulization after oral endotracheal intubation in patients undergoing general anesthesia.