Desloratadine: An Insight On Acute Inflammation

Abstract

In allergic inflammatory diseases, histamine plays a significant role. Histamine H1 receptor antagonists, also referred to as antihistamines, have been used to treat allergies for a long time. They are believed to work by inhibiting the inflammatory responses brought on by the release of histamine. Mast cells, basophils, lymphocytes, and other reservoirs contain granules that release histamine, a short peptide with inherent vasoactive properties. Histamine interacts with histamine receptors to control a number of cellular processes involved in the control of allergic inflammation and the immune system.Here, we examine mounting evidence that histamine does, in fact, play a part in inflammation and the regulation of immune function in these disorders. In particular, the identification of the fourth histamine receptor (H4) and its widespread expression on immunological and inflammatory cells.