Effect Of Chemotherapy On Lipid Profile And Insulin Resistance Among Post Mastectomy Women

Abstract

Background Breast cancer survival rates have been increased due to earlier detection and better care. Nevertheless, despite its effectiveness, adjuvant chemotherapy may have unintended adverse effects, because some women with breast cancer suffer from long‐term metabolic effects. The lipid profiles and insulin resistance in patients of breast cancer may be affected by a different types of therapies. This study designed to estimate the influence of chemotherapy on lipid profile in serum and insulin resistance by homeostasis model assessment (HOMA-IR) among post mastectomy women. Research design This study is an interventional study which carried to determine how chemotherapy will affect the lipid profile and insulin resistance. The research involved 116 patients in total. Results Our results revealed that there were a statistically significant rise in total cholesterol, triglycerides, LDL, VLDL cholesterol, fasting blood glucose, HOM-IR, and fasting insulin compared to the baseline before chemotherapy, whereas there was a statistically significant decline in high-density lipoprotein cholesterol. Conclusion Given that the adjuvant chemotherapy used to treat female breast cancer might result in severe changes in the blood lipid and glycemic profiles, frequent evaluations of these variables are required for follow-up care during management of breast cancer.