Treatment Outcome Of Gbm: A Retrospective Single Institutional Study

Abstract

Background: The most frequent malignant brain tumour is glioblastoma multiforme (GBM), with other CNS cancers accounting for 47.7% of all cases. The aim of the present study was to evaluate the effect of suggested predicting factors on survival of adult GBM patien. Patients and methods: This retrospective cohort analysis of adult GBM patients treated at clinical oncology, Zagazig University, Egypt. All demographic data, histopathological tumor types and grades were revised and adjusted according to WHO classification of CNS tumors (2016), surgical status, location, tumor morphology, treatment, outcome, recurrence, disease free survival and overall survival were collected and analyzed. Results:  The median age of patients was 53 years (with predominance of males to females.52.3%of patients was with a tumor size >5cm. most patients underwent initial surgery (79.3%) while remaining (20.7%) underwent  a diagnostic biopsy due to no respectability. Extent of resection was assessed by post.operative MRI in 85 patients (76.6%) of whom 3 ptients only underwent complete resection and 82 (73.9%) underwent partial resection Conclusion: The prognosis of adult patients with GBM remain poor, however, surgical resection and adjuvant treatments improve overall survival.  Age, surgical resection, size of residual tumor and adjuvant chemotherapy  have been identified as prognostic indicators of overall survival. Conclusion: The prognosis of adult patients with GBM remain poor, however, surgical resection and adjuvant treatments improve overall survival, age ,surgical resection, size of residual tumor and adjuvant chemotherapy  have been identified as prognostic indicators of overall survival.