ASSESSMENT OF INJECTION SITE REACTION IN PATIENTS TREATED WITH BIOLOGIC DRUGS FOR SUBCUTANEOUS ADMINISTRATION

Authors

  • Yulitza Geomara Villamar-Torres
  • Vilma Rocío Quijije Chavez
  • Mariuxi Zurita Desiderio

DOI:

https://doi.org/10.47750/pnr.2022.13.03.080

Keywords:

skin reactions, biologic drugs, rheumatoid arthritis.

Abstract

The present study aimed to evaluate skin reactions associated with biologic drugs administered subcutaneously. It was conducted at the Fundació Hospital de l'Espèrit Sant, Barcelona, Spain. The study population was considered to be patients who had a monthly and maximum 12-week treatment with subcutaneous administration of biologic drugs. The variables studied were those related in the first part to the clinical history: age, sex and diagnosis of the patient, additionally, the names of the drug and frequency of use were considered. A clinical interview was conducted on the self-administration of the drug, for example: if hands were washed before the application of the drug, placed on the body where the drug was administered, rotations of the puncture site and reactions at the puncture site. Among the most relevant results, the mean age of the patients was 54 years, the sex that influenced was male with 50.5%, and a prevalent diagnosis of rheumatoid arthritis with 32%. The most commonly used drug was adalimumab 60% with a frequent regimen every 2 weeks with 43%. It was presented that 90% of the patients washed their hands before administration, the preferential puncture site reported was the abdomen with 73%, and the puncture site was rotated in 82%. It was obtained that 4 patients out of a total of 99 patients evaluated had puncture site reactions, three with the drug adalimumab in the thigh and abdomen area; and one with etanercept in the abdomen area. Since this was a pilot test, the present research suggests continuing to explore other investigations that allow elucidating more conclusively if there is a relationship between the drugs used and their adverse reactions.

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Published

2022-09-16

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Section

Articles

How to Cite

ASSESSMENT OF INJECTION SITE REACTION IN PATIENTS TREATED WITH BIOLOGIC DRUGS FOR SUBCUTANEOUS ADMINISTRATION. (2022). Journal of Pharmaceutical Negative Results, 13(3), 523-528. https://doi.org/10.47750/pnr.2022.13.03.080